CBR launches
CBR now offers the option to add pediatric genetic testing onto your service. Each testing option checks for gene changes that may cause certain conditions, potentially allowing you to take proactive steps toward improving your child’s health.
A valuable partnership
Founded in 2011, Fulgent Genetics has transformed patient care by offering families the ability to be proactive about treatment, medications, and overall wellness. Custom pediatric genetic testing offered exclusively through CBR goes beyond the standard, state-mandated newborn screening to analyze more conditions and provide more certainty for families143—making it the perfect addition to CBR’s portfolio. CBR genetic tests are only available to expecting parents with residence in the USA.
Getting to know CBR's genetic testing partner, Fulgent Genetics
- A leader in next generation sequencing
- First commercial genetic test launched was focused on rare pediatric diseases
- Operates CLIA-certified & CAP-accredited labs across the US, with quality controls built into every step of the testing procedure
Genetic testing 101
The goal of genetic screening is to identify individuals who might be at risk for serious medical conditions. Our tests compare how variations in your child’s genes might be different from the general population. Thanks to decades of research, it’s often possible to determine whether specific variants are associated with a genetic condition.
Early detection of medical conditions may allow for faster diagnosis and treatment before symptoms appear.144 This allows you to potentially take proactive measures for your child which may include making healthy lifestyle changes or exploring preventive medical treatments. And, in the case of some rare disorders, early detection could even save your child’s life.144
Picture genetic testing options include analysis of as many as 1,500+ genes related to conditions including:
- Blood disorders
- Cancers
- Cardiovascular conditions
- Epilepsy
- Hearing and vision loss
- Immunodeficiency disorders
- Metabolic disorders
- Vision loss
- Other disorders
Options to fit your needs
Each of Picture’s three genetic testing tiers uses a simple cheek swab to screen for various conditions in your child.
CBR Snapshot™ test
- Analyzes 250+ genes138
- Goes beyond standard, state-mandated newborn screening to help determine whether your child is at risk for certain genetic conditions143
- Covers metabolic disorders, cancers, cardiovascular disorders, and hearing and vision loss
CBR Portrait™ test
- Analyzes 600+ genes138
- Covers everything included in CBR Snapshot, plus additional genes for hearing loss, actionable epilepsy, immunodeficiency, congenital heart defects, and neonatal diabetes
- Provides a deeper look at genetic conditions, allowing even more causes to be detected
CBR Landscape™ test
- Analyzes 1,500+ genes138
- Covers everything included in CBR Snapshot & CBR Portrait, plus additional genes associated with an even broader range of genetic conditions
- One of the most comprehensive pediatric genetic tests available138
- Includes pharmacogenetic (PGx) testing, which provides insight into how your child’s genetics may influence their response to 100+ medications
How genetic testing works
1
Order
Add a testing option to your cord blood or cord blood + cord tissue preservation and a genetic test kit will be mailed to you once your child is born. No doctor visit necessary!
Register & Collect
Simply register your kit online, use the provided cheek swab to collect your child’s DNA sample, and send it in using the prepaid postage envelope inside the kit.
2
3
Results
You will receive your child’s personalized genetic test results through the Picture Portal. CBR’s Clinical Team is available to answer questions about your results.
Common genetic testing FAQs
Picture® genetic testing is offered by CBR® (Cord Blood Registry®) in partnership with Fulgent Genetics. There are 3 product levels designed to meet the needs of every family. These tests offer families the opportunity to have screening for up to 1,500+ genes that may impact a child’s risk of developing certain genetic conditions. Our most comprehensive test option also includes pharmacogenetic (PGx) testing which provides insight to how the body may respond to 100+ medications that may be prescribed throughout a person’s lifetime.
Picture genetic testing options include as many as 1,500+ genes, including genes related to certain blood disorders, metabolic disorders, cancers, heart conditions, epilepsy, and hearing and vision loss.138 In the case of a positive result, meaning a potentially disease-causing genetic variant was identified, early detection may allow for faster diagnosis and treatment before symptoms appear.144 All three testing options include conditions that may be treated with medication, dietary modification, or other therapies. Examples of these conditions include:
- G6PD deficiency is a common inherited condition that can cause mild-to-severe anemia when a child is exposed to fava beans, artificial blue food coloring, or foods with sulfites (a common preservative). If a family knows a child has this condition, avoidance of triggers may help children with the condition lead a healthy life.
- Lipid storage disorders are a group of conditions that do not allow the body to breakdown lipids, or fats, that we need. A subset of lipid storage disorders, called sphingolipidoses, can be identified with Picture genetic testing. Without treatment, these conditions can lead to the accumulation of fat in the body and cause damage to organs, like the liver and brain. Early diagnosis of these conditions can lead to treatment including medication or stem cell transplant.
- Spinal muscular atrophy (SMA) is a genetic disease that affects the nervous system. An FDA approved molecular therapy may improve symptoms. Starting treatment for SMA early, before symptoms appear, may help a child gain the greatest benefit from treatment.
Pharmacogenetic (PGx) testing is a type of genetic testing that can tell us how someone breaks down or metabolizes certain medications. PGx testing can be helpful as part of personalized medicine -- a type of medical care in which treatment is customized for an individual patient. PGx results may provide information on how your child's body may potentially respond to certain drugs. Certain genetic variants may impact the metabolism of certain drugs, potentially making them more or less effective. Discussing these results with your child's healthcare provider may also potentially help avoid an adverse drug reaction (ADR), which is an unexpected, negative response to specific medications. PGx testing may help healthcare providers tailor what medications a person uses.145
- At the time of enrollment, expecting families enrolling with CBR for newborn stem cell preservation have the option to purchase Picture genetic testing.
- If you order a Picture genetic test, the kit will be shipped to your home after the birth of your child. This kit includes simple step-by-step instructions to help you with the cheek swab process.
- Once you receive the genetic testing kit, create a Picture Portal account with our genetic testing partner, Fulgent, at www.picturegenetics.com/portal/start-my-test/cbr.
- Activate your test kit in your Picture Portal account using the activation code inside the test kit. Complete the informed consent step and answer a few questions about family health history and the child who will be tested.
- Before starting the collection, read the instructions in the Genetic Test guide carefully and completely, making sure to follow each step provided.
- Collect your child’s sample using the buccal swab(s) included inside the test kit. Once you have collected your child’s sample(s), return them to the kit and send them to the Picture lab using the pre-paid shipping envelope inside the kit.
- Fulgent sequences and analyzes your child’s DNA at their advanced CLIA-certified lab. You can track the status of your child’s test on your Picture Portal account. You should receive the test results approximately three to five weeks after Picture receives your child’s sample in the mail.
- Once the analysis is complete, your child’s genetic testing report will be available on your Picture Portal account. You will receive an email when the test results are ready.
- After you receive your results, you can contact CBR’s Clinical Team at 1.888.267.3256 or at genetictest@cordblood.com with questions about your child’s Picture genetic test results.
See cordblood.com/enroll.
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