CBR is advancing potential newborn stem cell uses by partnering with leading research institutions to establish FDA-regulated clinical trials, exploring the use of a child’s own stem cells for conditions that currently have no cure. Cord blood stem cells are currently being evaluated as potential treatments for:
Sensorineural hearing loss (SNHL) is a specific type of hearing loss that involves damage to, or dysfunction of, the inner ear (as opposed to other structures of the ear). Acquired SNHL can happen as the result of premature birth, infections, or exposure to loud noise or to certain drugs, resulting in irreversible damage to the fragile hair cells (cilia) in the inner ear.105
Children who have low or high frequency hearing loss.103
Children whose SNHL has no genetic component (acquired).104
Young adults with hearing loss who experience a limitation in daily functioning.103
Infants born in the U.S. from 2005-2014 with hearing loss.103
Cord blood stem cells may have unique advantages:
Unlike other hearing loss treatments, early laboratory studies have shown that cord blood stem cells appear to address the underlying cause of hearing loss directly by helping to regenerate delicate structures within the inner ear.10
In laboratory studies, newborn stem cells have demonstrated the ability to hone in on the site of damage. They may also have the potential to spur the repair mechanism at that site.106
Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.
Autism, or Autism Spectrum Disorder (ASD), is a complex disorder with a wide range of signs and symptoms. No two children with autism are exactly alike, however, they may share commonalities such as difficulties with language and social interactions. Scientists are hoping to find new treatments that "calm" this overactive immune response to help protect the developing brain in young children with autism.
1 in 68 children have autism spectrum disorder (ASD).93
ASD is about 4.5 times more common among boys (1 in 42) than among girls (1 in 189).93
ASD occurs in all racial, ethnic, and socioeconomic groups.93
Most children are diagnosed with autism between this age range.93
Cord blood stem cells may have unique advantages:
Early research has shown that cells found in cord blood have the ability to regulate inflammation and migrate to the site of neurologic injury.96,97
The working theory is that the infused cells secrete factors that promote the body’s own repair mechanism in the surrounding tissue(s) via paracrine signaling, or what is commonly referred to as the bystander effect.98
Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.
Cerebral palsy is caused by a brain injury or lack of oxygen in the brain before or during birth or in the first few years of life. It can impair movement, learning, hearing, vision, and cognitive skills. Cerebral means having to do with the brain. Palsy means weakness or problems with using the muscles. CP is the most common motor disability in childhood.
According to the Centers for Disease Control and Prevention, it is estimated that roughly 1 in every 323 children in the United States has been diagnosed with cerebral palsy.
The majority of CP (85%–90%) is congenital. It is thought to be present from birth, although in many cases, the specific cause is not known.
The symptoms of Cerebral palsy, except in its mildest forms, can be evident in the first 12-18 months.
Cerebral palsy occurs in all racial, ethnic, and socioeconomic groups.
Cord blood stem cells may have unique advantages:
Early research has shown that cells found in cord blood have the ability to regulate inflammation and migrate to the site of neurologic injury.
Previous pre-clinical research has shown that umbilical cord blood (CB) contains effector cells that can suppress inflammation and alter synapse connectivity via paracrine signaling. Early trials have reported results suggesting cord blood infusion may have the potential to improve gross and fine motor function and increase whole brain connectivity.
Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.
Hunter Moore, CBR® patient and ambassador
Lisa and Glenn Moore had every expectation that their son, Hunter, was going to be a healthy baby boy, but they decided to preserve his newborn stem cells with CBR just in case. When Hunter was around 9 months old, they noticed differences in his mobility on the left side of his body. After being diagnosed with cerebral palsy, the cord blood they preserved would be used as part of his treatment.
Patrick Johnson, Justice's dad
After an 18-week anatomy scan revealed that Justice Johnson would be born with hydrocephalus, his parents - Alison and Patrick - began investigating treatment options and made the decision to preserve their baby's newborn stem cells with CBR®.
Armené K., Sasoun's mom
Baby Sasoun was diagnosed with Severe Combined Immunodeficiency Syndrome (SCID). This rare genetic disorder would most likely be fatal within the first year or two of life unless Sasoun received an immune-restoring treatment. Meet the incredible family and watch the story of Sasoun’s remarkable recovery made possible by his older brother’s newborn stem cells.
Sarah Huber, Grace's mom
Grace was born with a condition called sensorineural hearing loss. Because her parents preserved her newborn stem cells with CBR, she was connected to a clinical trial through the Family Health Registry.
Jessica Holemon, Abigail's mom
When Jessica gave birth to her second daughter, Abigail, she banked her newborn stem cells without knowing the health challenges that would lie ahead for her family. Watch how the seemingly simple decision to preserve turned out to make a big difference.
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