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Paving the way for further treatments
CBR is advancing potential newborn stem cell uses by partnering with leading research institutions to establish FDA-regulated clinical trials, exploring the use of a child’s own stem cells for conditions that currently have no cure. Cord blood stem cells are currently being evaluated as potential treatments for:
What is acquired sensorineural hearing loss?
Sensorineural hearing loss (SNHL) is a specific type of hearing loss that involves damage to, or dysfunction of, the inner ear (as opposed to other structures of the ear). Acquired SNHL can happen as the result of premature birth, infections, or exposure to loud noise or to certain drugs, resulting in irreversible damage to the fragile hair cells (cilia) in the inner ear.105
15%
Children who have low or high frequency hearing loss.103
50% - 70%
Children whose SNHL has no genetic component (acquired).104
40%
Young adults with hearing loss who experience a limitation in daily functioning.103
45,000
Infants born in the U.S. from 2005-2014 with hearing loss.103
The potential role of newborn stem cells
Cord blood stem cells may have unique advantages:
Targeted therapy
Unlike other hearing loss treatments, early laboratory studies have shown that cord blood stem cells appear to address the underlying cause of hearing loss directly by helping to regenerate delicate structures within the inner ear.10
Self-repair
In laboratory studies, newborn stem cells have demonstrated the ability to hone in on the site of damage. They may also have the potential to spur the repair mechanism at that site.106
Safe and accessible
Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.
What is autism?
Autism, or Autism Spectrum Disorder (ASD), is a complex disorder with a wide range of signs and symptoms. No two children with autism are exactly alike, however, they may share commonalities such as difficulties with language and social interactions. Scientists are hoping to find new treatments that "calm" this overactive immune response to help protect the developing brain in young children with autism.
1 in 68
1 in 68 children have autism spectrum disorder (ASD).93
4.5x
ASD is about 4.5 times more common among boys (1 in 42) than among girls (1 in 189).93
All backgrounds
ASD occurs in all racial, ethnic, and socioeconomic groups.93
2-6 years old
Most children are diagnosed with autism between this age range.93
The potential role of newborn stem cells
Cord blood stem cells may have unique advantages:
Anti-inflammatory properties
Early research has shown that cells found in cord blood have the ability to regulate inflammation and migrate to the site of neurologic injury.96,97
Bystander effect
The working theory is that the infused cells secrete factors that promote the body’s own repair mechanism in the surrounding tissue(s) via paracrine signaling, or what is commonly referred to as the bystander effect.98
Safe and accessible
Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.
What is cerebral palsy?
Cerebral palsy is caused by a brain injury or lack of oxygen in the brain before or during birth or in the first few years of life. It can impair movement, learning, hearing, vision, and cognitive skills. Cerebral means having to do with the brain. Palsy means weakness or problems with using the muscles. CP is the most common motor disability in childhood.
1 in 323
According to the Centers for Disease Control and Prevention, it is estimated that roughly 1 in every 323 children in the United States has been diagnosed with cerebral palsy.
85%-95%
The majority of CP (85%–90%) is congenital. It is thought to be present from birth, although in many cases, the specific cause is not known.
12-18 months
The symptoms of Cerebral palsy, except in its mildest forms, can be evident in the first 12-18 months.
All backgrounds
Cerebral palsy occurs in all racial, ethnic, and socioeconomic groups.
The potential role of newborn stem cells
Cord blood stem cells may have unique advantages:
Anti-inflammatory properties
Early research has shown that cells found in cord blood have the ability to regulate inflammation and migrate to the site of neurologic injury.
Bystander effect
Previous pre-clinical research has shown that umbilical cord blood (CB) contains effector cells that can suppress inflammation and alter synapse connectivity via paracrine signaling. Early trials have reported results suggesting cord blood infusion may have the potential to improve gross and fine motor function and increase whole brain connectivity.
Safe and accessible
Cord blood can be easily collected at the time of birth and stored for potential future use by the newborn donor or close family member.
Leading research institutions
Hear from those that know us best.
"When I was born, the doctors told my parents I would never walk. I would never be able to talk, and I'd be in a wheelchair my whole life."
Hunter Moore, CBR® patient and ambassador
Lisa and Glenn Moore had every expectation that their son, Hunter, was going to be a healthy baby boy, but they decided to preserve his newborn stem cells with CBR just in case. When Hunter was around 9 months old, they noticed differences in his mobility on the left side of his body. After being diagnosed with cerebral palsy, the cord blood they preserved would be used as part of his treatment.
"If we didn’t preserve his newborn stem cells, I don’t know what life would be like."
Patrick Johnson, Justice's dad
After an 18-week anatomy scan revealed that Justice Johnson would be born with hydrocephalus, his parents - Alison and Patrick - began investigating treatment options and made the decision to preserve their baby's newborn stem cells with CBR®.
"Newborn stem cell preservation gave our son a future."
Armené K., Sasoun's mom
Baby Sasoun was diagnosed with Severe Combined Immunodeficiency Syndrome (SCID). This rare genetic disorder would most likely be fatal within the first year or two of life unless Sasoun received an immune-restoring treatment. Meet the incredible family and watch the story of Sasoun’s remarkable recovery made possible by his older brother’s newborn stem cells.
"For all the parents out there considering preserving their newborn stem cells, I can't stress how important it is… we're so happy we did this."
Sarah Huber, Grace's mom
Grace was born with a condition called sensorineural hearing loss. Because her parents preserved her newborn stem cells with CBR, she was connected to a clinical trial through the Family Health Registry.
"We have faith that no matter what, this will impact the rest of her life."
Jessica Holemon, Abigail's mom
When Jessica gave birth to her second daughter, Abigail, she banked her newborn stem cells without knowing the health challenges that would lie ahead for her family. Watch how the seemingly simple decision to preserve turned out to make a big difference.
